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2023 2

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CPAL 1

Inflammation 1

Myocardial infarction 1

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CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction Article

Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang

Engineering 2023, Volume 20, Issue 1,   Pages 49-62 doi: 10.1016/j.eng.2022.08.012

Abstract: identify a previously unknown conserved lncRNA, AK009126 (cardiomyocyte pyroptosis-associated lncRNA, CPALImportantly, the adeno-associated virus 9 (AAV9)-mediated silencing of endogenous CPAL by its short hairpinMechanistically, CPAL is shown to bind directly to nuclear factor kappa B (NFκB) and to act asWe also find that CPAL upregulates caspase-1 expression at the transcriptional level and consequentlyand cardiomyocyte pyroptosis in the setting of MI and suggest CPAL as a new therapeutic target to protect

Keywords： Myocardial infarction     Pyroptosis     CPAL     NFκB     Inflammation    

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Title Author Date Type Operation

CPAL, as a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis, Regulates Myocardial Infarction

Jiamin Li, Hongru Xue, Ning Xu, Liling Gong, Ming Li, Sijia Li, Di Huang, Qingwei Zhang, Pengyu Li, Qingsui Li, Hang Yu, Yining Liu, Yadong Xue, Haixin Chen, Jiali Liu, Wanyu Zhang, Mingbin Liu, Siyu Chang, Xianzhi Lang, Xingmiao Zhao, Weijie Du, Benzhi Cai, Ning Wang, Baofeng Yang

Journal Article

Wang Ning：CPAL，a New Mediator of Cardiomyocyte Metabolic Alterations and Pyroptosis（2023-2-21）

2 Mar 2023

Conference Videos